Suspension-Induced Murine Keratinocyte Differentiation Is Mediated by Calcium
نویسندگان
چکیده
منابع مشابه
Genes Are Mediated by Protein Kinase C - Ha ras Activated Alterations in Murine Keratinocyte Differentiation Induced by Updated
Primary mouse keratinocytes expressing the v.ras@I*oncogene keratinocytes) produce squamous papillomas when grafted onto nude mice and respond abnormally to signals for terminal differentiation both in vivo and in vitro. Since protein kinase C (PKC) activators and v@ras@I* induce similar phenotypic changes in cultured keratinocytes, and cellular diacylglycerol levels are constitutively elevated...
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Keratinocyte differentiation requires integrating signaling among intracellular ionic changes, kinase cascades, sequential gene expression, cell cycle arrest, and programmed cell death. We now show that Cl(-) intracellular channel 4 (CLIC4) expression is increased in both mouse and human keratinocytes undergoing differentiation induced by Ca(2+), serum and the protein kinase C (PKC)-activator, ...
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BACKGROUND We are continually exposed to low-dose radiation (LDR) in the range 0.1 Gy from natural sources, medical devices, nuclear energy plants, and other industrial sources of ionizing radiation. There are three models for the biological mechanism of LDR: the linear no-threshold model, the hormetic model, and the threshold model. OBJECTIVE We used keratinocytes as a model system to invest...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1996
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12340654